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Study identifier: NCT05918094 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Comparing Modified XELOX Plus Sintilimab With Standard XELOX Plus Sintilimab in First-line Treatment for HER2-negative Gastric/Gastroesophageal Junction Adenocarcinoma

Condition: Gastric Cancer  ·  Sponsor: Sun Yat-sen University

PhasePhase 3
Planned participants540
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a randomized, controlled, multicenter phase Ⅲ study to evaluate the therapeutic efficacy of modified XELOX plus sintilimab versus standard XELOX plus sintilimab in subjects with advanced HER2-negative gastric or gastroesophageal adenocarcinoma in the first-line treatment. The primary outcome is the progression-free survival (PFS), with a planned enrollment of 540 subjects.

This description comes directly from the study's public registry record.

Talk to the study team

Ruihua Xu, MD  ·  +86 20 87343795  ·  xurh@sysucc.org.cn

Feng Wang, MD, PhD  ·  +86 20 87343795  ·  wangfeng@sysucc.org.cn

Always discuss trial participation with your own doctor first.

Locations (10)

Sun Yat-sen University Cancer CenterGuangzhou, Guangdong, ChinaRecruiting
The Affliated Cancer Hospital of Guizhou Medical UniversityGuiyang, Guizhou, ChinaRecruiting
Harbin Medical University Cancer HospitalHarbin, Heilongjiang, ChinaNot Yet Recruiting
Henan Cancer HospitalZhengzhou, Henan, ChinaNot Yet Recruiting
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhan, Hubei, ChinaNot Yet Recruiting
The First Affiliated Hospital of Nanchang UniversityNanchang, Jiangxi, ChinaNot Yet Recruiting
The Second Hospital of Dalian Medical UniversityDalian, Liaoning, ChinaRecruiting
Ruijin Hospital, Shanghai Jiaotong University School of MedicineShanghai, Shanghai Municipality, ChinaNot Yet Recruiting
West China Hospital of Sichuan UniversityChengdu, Sichuan, ChinaNot Yet Recruiting
The Second Affiliated Hospital of Kunming Medical UniversityKunming, Yunnan, ChinaNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT05918094