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Study identifier: NCT05916339 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

AWARE: Management of ADHD in Autism Spectrum Disorder

Condition: ADHD · Autism Spectrum Disorder  ·  Sponsor: Daniel Coury

PhasePhase 4
Planned participants500
Who can joinAll sexes, 4 Years to 17 Years
Healthy volunteersNo

About this study

This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism. Using a sequential, multiple assignment randomization trial (SMART) design the study will not only assess these two medications but also the role of an increasingly popular class of ADHD medication, the alpha-2 agonists. Findings from this study will help improve clinicians' approach to medication selection and reduce the repeated trials of multiple medications that are current standard care.

This description comes directly from the study's public registry record.

Talk to the study team

Amanda James, BS  ·  (614) 722-4006  ·  Amanda.James@nationwidechildrens.org

Samantha Sharpe  ·  (614) 722-8509  ·  Samantha.Sharpe@nationwidechildrens.org

Always discuss trial participation with your own doctor first.

Locations (12)

University of California, IrvineIrvine, California, United StatesRecruiting
Children's Hospital Los AngelesLos Angeles, California, United StatesRecruiting
Maine Medical CenterPortland, Maine, United StatesRecruiting
Massachusetts General Hospital Lurie Center for AutismBoston, Massachusetts, United StatesRecruiting
University of RochesterRochester, New York, United StatesRecruiting
Cincinnati Children's Hospital Medical CenterCincinnati, Ohio, United StatesRecruiting
Nationwide Children's HospitalColumbus, Ohio, United StatesRecruiting
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting
University of PittsburghPittsburgh, Pennsylvania, United StatesRecruiting
University of VirginiaCharlottesville, Virginia, United StatesRecruiting
University of Alberta, Glenrose Rehabilitation HospitalEdmonton, CanadaRecruiting
Holland Bloorview Kids Rehabilitation HospitalToronto, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05916339