Condition: Oligometastatic Prostate Cancer · Sponsor: Catherine Spina
This study will evaluate the safety and effectiveness of a combination of study drugs including zimberelimab, etrumadenant, and quemliclustat in combination with metastasis-directed irradiation in men with hormone sensitive oligometastatic prostate cancer. The study aims to test the hypothesis that targeted inhibition of the adenosine signaling axis (quemliclustat (CD73 antagonist) + etrumadenant (A2AR/A2BR antagonist)) and immune checkpoint inhibition (zimberelimab, α-PD-1) in combination with metastasis-directed stereotactic body radiation therapy (SBRT) will improve local control, progression-free survival (PFS), and hormone therapy-free survival and mitigate immunosuppressive changes to the tumor microenvironment (TME), compared to SBRT alone.
This description comes directly from the study's public registry record.
Catherine S. Spina, MD, PhD · 212-305-7406 · css2190@cumc.columbia.edu
Research Nurse Navigator · 212-342-5162 · cancerclinicaltrials@cumc.columbia.edu
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| Columbia University Irving Medical Center / NewYork-Presbyterian Hospital | New York, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05915442