Condition: Beta-amiloid and Phospho-tau Proteins in CSF · Ventricular Size After CSF Shunt · Cognitive Impairment and CSF Shunt · Sponsor: University of Valencia
In all published series of adult chronic hydrocephalus, there is a percentage between twenty and twenty-five percent of patients who present poor results after implantation of a cerebrospinal fluid shunt,1-11 usually ventriculoperitoneal. The lumboperitoneal shunt is also used but much more rarely. The diagnosis of this pathology is based on the clinical picture, neuroimaging studies (Evans index and corpus callosum angle), cerebrospinal fluid dynamics tests (Katzman test), and invasive intracranial pressure measurements. Despite all this diagnostic arsenal, there is a high percentage of patients (mentioned above) in which treatment by diversion of cerebrospinal fluid does not offer the expected results. Traditionally, this has been attributed to chronic adult hydrocephalus being associated with other types of dementia. This may be the case in some patients, and it would be important to predict which patients will not improve or who will improve poorly in the case of insertion of a cerebrospinal fluid shunt.
This description comes directly from the study's public registry record.
Vicente Vanaclocha, Full Professor · +34 963 13 18 00 · vicente.vanaclocha@uv.es
Clinical Research Support Office · investigacion.hguv@gva.es
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| Hospital General Universitario de Valencia | Valencia, Valencia, Spain | Recruiting |
| Vicente Vanaclocha | Valencia, Valencia, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05915000