Condition: Waldenstrom Macroglobulinemia · Sponsor: Institute of Hematology & Blood Diseases Hospital, China
This study aims to evaluate the long-term efficacy of BTK inhibitor Zanubrutinib combined bendamustine and rituximab (ZBR) for time-limited treatment of Waldenstrom macroglobulinemia, The combination therapy is expected to improve the remission depth, prolong the remission time, and improve the progression-free survival and overall survival of newly diagnosed WM patients. On the one hand, the patients have to bear a long-term economic burden, which is often difficult for some patients to adhere to for a long time. On the other hand, in the course of long-term treatment of BTKi, drug resistance and intolerable side effects are prone to occur. At the same time, it can prevent the disease rebound after the withdrawal of BTKi, so as to achieve the phased withdrawal of WM
This description comes directly from the study's public registry record.
Shuhua Yi, Dr. · 86-22-23909106 · yishuhua@ihcams.ac.cn
Lugui Qiu, Dr. · 86-22-23909172 · qiulg@ihcams.ac.cn
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| Institute of Hematology & Blood Diseases Hospital | Tianjin, Tianjin Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05914662