Condition: Dementia, Frontotemporal · Alzheimer Dementia (AD) · Lewy Body Dementia (LBD) · Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
The causes of neurodegenerative dementias such as Frontotemporal Dementia, Lewy Body Disease and Alzheimer's disease are still largely unknown. While the contribution of some genetic mutations and polymorphisms is associated with autosomal dominant patterns of inheritance of these dementias, in many cases, the specific causative mutation in these families is not yet identified. Further, in many patients, polygenic risk is thought to give rise to pathophysiologic changes, but which specific genes affect risk are largely yet unknown. By examining genotypes in patients that present to our Cognitive Neurology and Alzheimer's Research Clinic with suspected or confirmed neurodegenerative dementia, or have a history of a familial dementia, we aim to help identify and characterize genetic mutations or polymorphisms that give rise to neurodegenerative diseases.
This description comes directly from the study's public registry record.
Sarah Jesso · 519-646-6000 · cognitiveneurology@sjhc.london.on.ca
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| Parkwood Institute | London, Ontario, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05911932