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Study identifier: NCT05908409 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase 1/2 Study of IDP-121 in Patients With Relapsed/Refractory Hematologic Malignancies

Condition: Multiple Myeloma (MM) · Diffuse Large B-Cell Lymphoma, Not Otherwise Specified · Double Hit Lymphoma  ·  Sponsor: IDP Discovery Pharma S.L.

PhasePhase 1/Phase 2
Planned participants37
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The main aims of this 2-part study are: * Phase I: To determine the maximum tolerated dose (MTD) and the recommended phase 2 dose (RP2D) of IDP-121 in patients with multiple myeloma (MM), diffuse large B cell lymphoma not otherwise specified (DLBCL-NOS), high-grade B cell lymphoma with double or triple hit rearrangement (HGBL-DH/TH) and HGBL-NOS, and chronic lymphocytic leukemia (CLL). * Phase II: To evaluate the overall response rate (ORR), duration of response (DoR), time to progression (TTP), progression-free survival (PFS), event-free survival (EFS) and Overall survival (OS), in patients with MM, DLBCL-NOS, HGBL-DH/TH, HGBL-NOS or CLL treated with IDP-121 at the recommended Phase 2 Dose (RP2D).

This description comes directly from the study's public registry record.

Talk to the study team

David Molina, PhD  ·  +34669616086  ·  d.molina@idp-pharma.com

Laura Nevola, PhD  ·  +34622540215  ·  l.nevola@idp-pharma.com

Always discuss trial participation with your own doctor first.

Locations (11)

Hospital Universitario Marques de ValdecillaSantander, Cantabria, SpainRecruiting
Hospital Universitario de SalamancaSalamanca, Castille and León, SpainRecruiting
Hospital Universitari Vall d'hebronBarcelona, SpainRecruiting
Hospital Durán i Reynals - ICO L´HospitaletBarcelona, SpainRecruiting
Hospital Universitario 12 de OctubreMadrid, SpainRecruiting
Hospital Universitario La PazMadrid, SpainRecruiting
Hospital Universitario Puerta de HierroMadrid, SpainRecruiting
Hospital Clínico Universitario Virgen de la ArrixacaMurcia, SpainRecruiting
Hospital Universitario Virgen del RocioSeville, SpainRecruiting
Hospital de Clinico Universitario de ValenciaValencia, SpainRecruiting
Hospital Universitario Miguel ServetZaragoza, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT05908409