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Study identifier: NCT05905315 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Primary Chemoradiation VS. Neoadjuvant Chemotherapy Followed By Surgery As Treatment Strategy For LAVC

Condition: Locally Advanced Vulvar Carcinoma · Squamous Cell Carcinoma of the Vulva  ·  Sponsor: The Netherlands Cancer Institute

PhasePhase 2
Planned participants98
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

A phase 2 randomised controlled trial will be performed in which the efficacy and safety of standard treatment (primary chemoradiation; consisting of 64.5 Gy in 30 fractions of external beam radiotherapy with weekly cisplatin for six weeks) and experimental treatment (NACT; consisting of carboplatin and paclitaxel in a 3-weekly scheme) will be compared in 98 patients with LAVC, registered from eight national medical centres.

This description comes directly from the study's public registry record.

Talk to the study team

Frederic Amant, Prof.  ·  0031205129111  ·  f.amant@nki.nl

Always discuss trial participation with your own doctor first.

Locations (2)

NKI-AVLAmsterdam, NetherlandsRecruiting
LUMCLeiden, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT05905315