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Study identifier: NCT05904106 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML

Condition: Acute Myeloid Leukemia  ·  Sponsor: Technische Universität Dresden

PhasePhase 2
Planned participants146
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

This phase II clinical trial evaluates the efficacy and tolerability of the non-intensive treatment with venetoclax and the hypomethylating agent azacitidine as compared to the standard of care chemotherapy plus gemtuzumab ozogamicin in newly diagnosed NPM1 mutated AML patients fit for intensive chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Manja Reimann, Dr.  ·  +49 351 458  ·  vincent@ukdd.de

Frank Fiebig  ·  +49 351 458  ·  vincent@ukdd.de

Always discuss trial participation with your own doctor first.

Locations (18)

Universitätsklinikum EssenEssen, North Rhine-Westphalia, GermanyRecruiting
Universitätsklinikum AachenAachen, GermanyRecruiting
Universitätsklinikum AugsburgAugsburg, GermanyRecruiting
Klinikum Chemnitz gGmbHChemnitz, GermanyRecruiting
Universiätsklinikum KölnCologne, GermanyNot Yet Recruiting
Universitätsklinikum DresdenDresden, GermanyRecruiting
Universitätsklinikum ErlangenErlangen, GermanyRecruiting
Johann Wolfgang Goethe-UniversitätFrankfurt am Main, GermanyRecruiting
Universitätsklinikum HalleHalle, GermanyRecruiting
Universitätsklinikum HeidelbergHeidelberg, GermanyRecruiting
Universitätsklinikum Schleswig-HolsteinKiel, GermanyRecruiting
Universitätsklinikum LeipzigLeipzig, GermanyRecruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05904106