Condition: Glioblastoma · Recurrent Glioblastoma · GBM · Sponsor: CarThera
The brain is protected from any toxic or inflammatory molecule by the blood-brain barrier (BBB). This physical barrier is located at the level of the blood vessel walls. Because of these barrier properties, the blood vessels are also impermeable to the passage of therapeutic molecules from the blood to the brain. The development of effective treatments against glioblastoma is thus limited due to the BBB that prevents most drugs injected in the bloodstream from getting into brain tissue where the tumour is seated. The SonoCloud-9 (SC9) is an investigational device using ultrasound technology and specially developed to open the BBB in the area of and surrounding the tumour. The transient opening of the BBB allows more drugs to reach the brain tumour tissue. Carboplatin is a chemotherapy that is approved to treat different cancer types alone or in combination with other drugs, and has been used in the treatment of glioblastoma. Despite its proven efficacy in the laboratory on glioblastoma cells, carboplatin does not readily cross the BBB in humans. A clinical trial has shown that in combination with the SonoCloud-9, more carboplatin can reach the brain tumour tissue. The objective of the proposed trial is to show that the association - carboplatin with the SonoCloud-9 - will increase efficacy of the drug in patients with recurrent glioblastoma.
This description comes directly from the study's public registry record.
Carole Desseaux · +33 472 626 268 · contact@carthera.eu
Always discuss trial participation with your own doctor first.
| Mayo Clinic Arizona | Phoenix, Arizona, United States | Active Not Recruiting |
| University of California, San Francisco | San Francisco, California, United States | Active Not Recruiting |
| UCHealth | Aurora, Colorado, United States | Recruiting |
| Mayo Clinic of Jacksonville Florida | Jacksonville, Florida, United States | Active Not Recruiting |
| Miami Cancer Institute | Miami, Florida, United States | Recruiting |
| Moffitt Cancer Center | Tampa, Florida, United States | Active Not Recruiting |
| Winship Cancer Institute at Emory University | Atlanta, Georgia, United States | Recruiting |
| Northwestern University | Chicago, Illinois, United States | Recruiting |
| Indiana University Health | Indianapolis, Indiana, United States | Recruiting |
| John Hopkins University | Baltimore, Maryland, United States | Active Not Recruiting |
| Mayo Clinic Rochester | Rochester, Minnesota, United States | Active Not Recruiting |
| Weill Cornell Medicine | New York, New York, United States | Active Not Recruiting |
+ 39 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05902169