Condition: Fibromyalgia Syndrome · Sponsor: University of Utah
The main purpose of the project is to evaluate the safety and efficacy of low dose metformin for improving symptoms associated with fibromyalgia syndrome (FMS) via modulating neuroinflammatory pathways. The investigators hypothesize that FMS patients in the low-dose metformin conditions will show greater improvement in FMS symptoms than those who are in the placebo group. Further, the investigators hypothesize that metformin will increase phosphorylated AMPK in peripheral immune cells of FMS patients and will decrease the transcription of mTORC1, NLRP3 inflammasome, and nociceptive cytokines interleukin 1beta and interleukin 18.
This description comes directly from the study's public registry record.
Reiko Mitsunaga, RN · 801-585-7695 · reiko.mitsunaga@hsc.utah.edu
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| University of Utah | Salt Lake City, Utah, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05900466