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Study identifier: NCT05899582 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Extracranial-intracranial Bypass Surgery for Symptomatic Chronic Middle Cerebral Artery Occlusion: the CMOSS-2 Trial

Condition: Symptomatic Chronic Middle Cerebral Artery Occlusion · Infarction, Middle Cerebral Artery  ·  Sponsor: Xuanwu Hospital, Beijing

PhaseNA
Planned participants420
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The CMOSS-2 trial is a government-funded, prospective, multicenter, randomized controlled trial. It will recruit symptomatic chronic occlusion of the middle cerebral artery in patients with severe hemodynamic insufficiency. Only high-volume center with a proven track record will be included. Patients will be randomized (1:1) to best medical treatment alone or medical treatment plus bypass surgery. Primary outcome is ischemic stroke in the territory of the target artery within 24 months after randomization.

This description comes directly from the study's public registry record.

Talk to the study team

Yan Ma, MD  ·  13810669502  ·  leavesyan@sina.com

Tao Wang, MD  ·  18810302298  ·  wangtao_dr@sina.com

Always discuss trial participation with your own doctor first.

Locations (1)

Xuanwu Hospital, Capital Medical University.Beijing, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT05899582