Condition: Melanoma · Sponsor: University of Aarhus
Surgery is a key element in the treatment of melanoma, and naturally linked with an inflammatory response and recruitment of innate immune cells. Although surgery has a favorable intent, surgery-induced inflammation, neutrophils in particular, may accelerate growth of local and systemic micrometastases. Thus, improving cancer surgery and modulating the wound microenvironment in ways that benefit the patients is crucial. Repurposing already approved drugs in a cancer setting has gained increasing interest in recent years. Interestingly, tranexamic acid was recently suggested as an anti-cancer drug, capable of reducing tumor growth in experimental animal models and reducing the viability of different melanoma cell lines. As a novel approach, sponsor and investigators will conduct a Randomised Clinical Trial, using perioperative treatment with Tranexamic Acid, aiming to prevent the early relapses for patients with melanoma.
This description comes directly from the study's public registry record.
Marie Louise Bønnelykke-Behrndtz, MD, PhD · +45 78 45 00 00 · marboe@rm.dk
Karoline Kristjansen, MD · karoline_kristjansen@clin.au.dk
Always discuss trial participation with your own doctor first.
| Aarhus University Hospital. Dept. of Plastic- and Breast Surgery | Aarhus, Central Jutland, Denmark | Recruiting |
| Aalborg University Hospital. Dept. of Plastic- and Breast Surgery. | Aalborg, North Denmark, Denmark | Recruiting |
| Copgenhagen University Hospital, Rigshospitalet. Dept. of Plastic Surgery and Burns Treatment | Copenhagen, Denmark | Recruiting |
| Copenhagen University Hospital, Herlev. Dept. of Plastic Surgery | Herlev, Denmark | Active Not Recruiting |
| Sygehus Lillebælt, Vejle Hospital. Dept. of Plastic Surgery | Vejle, Denmark | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT05899465