Condition: Shock · Sponsor: Università Vita-Salute San Raffaele
Shock is a major risk factor for mortality among patients admitted to intensive care units (ICUs). Since various hemodynamic strategies uniformly delivered to patients with shock have failed to improve clinically relevant outcomes, individualized approaches for shock supported by robust evidence are required. This study will be a prospective, multicenter, parallel-group, single-blind, randomized controlled trial. The investigators will randomly assign 800 critically ill patients requiring norepinephrine infusion to the renin-guided or usual care groups. The investigators hypothesize that renin-guided hemodynamic management, compared to usual care, can reduce a composite of mortality and acute kidney injury (AKI) progression in patients requiring vasopressor support.
This description comes directly from the study's public registry record.
Alessandro Belletti, MD · 0039 0226436151 · belletti.alessandro@hsr.it
Nicola Buzzatti, MD · 0039 0226436151 · buzzatti.nicola@hsr.it
Always discuss trial participation with your own doctor first.
| University Hospital Dubrava | Dubrava, Croatia | Recruiting |
| Ospedale Mater Domini | Catanzaro, Calabria, Italy | Not Yet Recruiting |
| IRCCS Ospedale San Raffaele | Milan, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05898126