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Study identifier: NCT05896293 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Kisspeptin Administration Subcutaneously to Patients With IHH

Condition: Hypogonadotropic Hypogonadism  ·  Sponsor: Stephanie B. Seminara, MD

PhasePhase 2
Planned participants36
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in men and women with idiopathic hypogonadotropic hypogonadism (IHH). The investigators are also examining whether kisspeptin can help women release eggs from their ovaries. Kisspeptin will be administered SC for two weeks in a pulsatile fashion. Ultrasound monitoring of ovarian follicular growth (for women) and frequent blood sampling (every 10 minutes for up to 70 minutes) will be performed to assess the physiologic response to kisspeptin over time. Funding Source: FDA OOPD

This description comes directly from the study's public registry record.

Talk to the study team

Study Coordinator  ·  617-726-1895  ·  MGHKisspeptinResearch@partners.org

Always discuss trial participation with your own doctor first.

Locations (1)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05896293