Condition: Major Depressive Disorder · Sponsor: University of Utah
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression. Subjects will be randomized between 5-HTP 100mg BID + creatine 5g daily, 5-HTP 200mg BID + creatine 10g daily, vs double placebo, for 8 weeks. The ability of the interventions to affect biomarkers associated with depression will be assessed using brain phosphorus magnetic resonance spectroscopy, functional connectivity imaging, and plasma serotonin levels.
This description comes directly from the study's public registry record.
Brent Kious, MD · 8015851418 · brent.kious@hsc.utah.edu
Hailey Nielson, MS · 801-581-3475 · hailey.nielson@utah.edu
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| University of Utah Department of Psychiatry | Salt Lake City, Utah, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05895747