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Study identifier: NCT05894239 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

Condition: Metastatic Breast Cancer  ·  Sponsor: Hoffmann-La Roche

PhasePhase 3
Planned participants230
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will evaluate the efficacy and safety of inavolisib in combination with Phesgo (pertuzumab, trastuzumab, and rHuPH20 injection for subcutaneous use) compared with placebo in combination with Phesgo, as maintenance therapy, after induction therapy in participants with previously untreated HER2-positive advanced breast cancer (ABC).

This description comes directly from the study's public registry record.

Talk to the study team

Reference Study ID Number: WO44263 https://forpatients.roche.com/ No attachments to email below.  ·  888-662-6728 (U.S. Only)  ·  global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Always discuss trial participation with your own doctor first.

Locations (192)

Banner Health MD Anderson AZGilbert, Arizona, United StatesRecruiting
Disney Family Cancer CenterBurbank, California, United StatesRecruiting
City of HopeCorona, California, United StatesRecruiting
City of Hope Comprehensive Cancer CenterDuarte, California, United StatesRecruiting
City of Hope at Irvine LennarIrvine, California, United StatesRecruiting
Ellison Institute of TechnologyLos Angeles, California, United StatesRecruiting
Georgetown Uni HospitalWashington D.C., District of Columbia, United StatesRecruiting
Medstar Research InstituteHyattsville, Maryland, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Henry Ford HospitalDetroit, Michigan, United StatesRecruiting
Renown Regional Medical CenterReno, Nevada, United StatesWithdrawn
Hackensack University Medical CenterHackensack, New Jersey, United StatesWithdrawn

+ 180 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05894239