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Study identifier: NCT05892965 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Instant Message-delivered Brief Internet-based Cognitive Behavioural Therapy (iCBT) for Post-stroke Depression

Condition: Stroke · Depressive Symptoms · Mobile Phone Use  ·  Sponsor: The University of Hong Kong

PhaseNA
Planned participants160
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Around one third of stroke survivors develop depression at any point of time following the stroke event. Post-stroke depression (PSD) is associated with negative care outcomes including poorer function, longer hospital stays, increased outpatient and inpatient clinic use, and higher mortality rate. In Hong Kong (HK), the prevalence of PSD within the hospital setting was 36%, and up to 68% in the community setting. However, PSD is seldom addressed in either settings in HK and elsewhere. Meta-analyses reported the effectiveness of Internet-based cognitive behavioural therapy (iCBT), particularly when guided by therapists (d = 0.63). Personalised and synchronous instant message-based intervention guided by therapists is an emerging form of psychological intervention. While such intervention showed medium to large effect (Hedges' g = 0.73) on negative psychological distress episodes including depression, no study has investigated its effect on PSD. The proposed study aims to 1) investigate the effect of therapist-guided brief iCBT delivery through instant messaging applications (e.g. WhatsApp and WeChat) to provide personalised and synchronous PSD support and 2) understand the experience of and compliance with the intervention. 160 community-dwelling stroke survivors with Patient Health Questionnaire-9 (PHQ-9) scores ranging from 5 to 19 indicating mild to moderate depressive symptoms will be recruited and then individually randomised into the Intervention group (n=80) or Control…

This description comes directly from the study's public registry record.

Talk to the study team

Jung Jae LEE  ·  +85239176971  ·  leejay@hku.hk

Always discuss trial participation with your own doctor first.

Locations (7)

Hong Kong PHAB AssociationHong Kong, Hong KongRecruiting
Hong Kong Stroke AssociationHong Kong, Hong KongRecruiting
NT West Community Rehabilitation Day CentreHong Kong, Hong KongNot Yet Recruiting
Queen Mary HospitalHong Kong, Hong KongRecruiting
The Hong Kong Society for RehabilitationHong Kong, Hong KongRecruiting
Tung Wah HospitalHong Kong, Hong KongRecruiting
United Christian HospitalHong Kong, Hong KongRecruiting

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Source record: clinicaltrials.gov/study/NCT05892965