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Study identifier: NCT05892744 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Establishing Multimodal Brain Biomarkers for Treatment Selection in Depression

Condition: Major Depressive Disorder · Chronic Major Depression, Recurrent  ·  Sponsor: University of Texas at Austin

PhasePhase 4
Planned participants50
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The purpose of the study is to identify brain biomarkers and characteristics that predict individual responses to treatment of major depression with the antidepressant drug sertraline (tradename Zoloft), a common selective serotonin reuptake inhibitor (SSRI) antidepressant. Our central hypothesis is that brain activity and connections jointly measured with functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) will be able to predict an individual's response to sertraline treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Greg Fonzo, Ph.D.  ·  512-495-5856  ·  fonzolab@austin.utexas.edu

Lauren Enten, B.S.A  ·  lauren.enten@austin.utexas.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600Austin, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05892744