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Study identifier: NCT05892510 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke

Condition: Ischemic Stroke, Acute · Cerebrovascular Disorders · Brain Disorder  ·  Sponsor: University of Melbourne

PhasePhase 2/Phase 3
Planned participants462
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Multicentre, prospective, Multi-arm Multi-stage (MAMS) seamless phase 2b/3 interventional randomized placebo-controlled double-blinded parallel-assignment (2 arms with 1:1 randomization) efficacy and safety trial to test intra-arterial tenecteplase at the completion of thrombectomy versus best practice in participants with anterior circulation LVO receiving mechanical thrombectomy within 24 hours of symptoms onset.

This description comes directly from the study's public registry record.

Talk to the study team

Felix Ng  ·  +03 9342 7000  ·  ng.f@unimelb.edu.au

Always discuss trial participation with your own doctor first.

Locations (12)

Gold Coast Univeristy HospitalGold Coast, Queensland, AustraliaRecruiting
Royal Adelaide HospitalAdelaide, AustraliaRecruiting
Alfred HospitalMelbourne, AustraliaRecruiting
Austin HospitalMelbourne, AustraliaRecruiting
Monash Medical CentreMelbourne, AustraliaRecruiting
Royal Melbourne HospitalMelbourne, AustraliaRecruiting
Fiona Stanley HospitalPerth, AustraliaRecruiting
Sir Charles Gairdner HospitalPerth, AustraliaRecruiting
Liverpool HospitalSydney, AustraliaRecruiting
Royal North Shore HospitalSydney, AustraliaRecruiting
Townsville University HospitalTownsville, AustraliaRecruiting
Christchurch HospitalChristchurch, New ZealandNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT05892510