Condition: Grade 3b Follicular Lymphoma · High Grade B-Cell Lymphoma · High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements · Sponsor: SWOG Cancer Research Network
This phase 2 trial studies the side effects and best dose of tazemetostat and zanubrutinib in combination with tafasitamab and lenalidomide, and to see how well these combinations work in treating patients with large B-cell lymphoma that returned or did not respond to earlier treatment. Tazemetostat is in a class of medications called EZH2 inhibitors. It helps to stop the spread of cancer cells. Zanubrutinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells. tafasitamab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Lenalidomide is in a class of medications called immunomodulatory agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells in the bone marrow. The addition of tazemetostat or zanubrutinib to tafasitamab and lenalidomide may be able to shrink the cancer or extend the time without cancer symptoms coming back.
This description comes directly from the study's public registry record.
Katarina Gasic · 210-677-8808 · kgasic@swog.org
Crystal Miwa · 210-677-8808 · cmiwa@swog.org
Always discuss trial participation with your own doctor first.
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | Recruiting |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | Recruiting |
| Tower Cancer Research Foundation | Beverly Hills, California, United States | Recruiting |
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | Recruiting |
| City of Hope Seacliff | Huntington Beach, California, United States | Recruiting |
| City of Hope Antelope Valley | Lancaster, California, United States | Recruiting |
| City of Hope at Long Beach Elm | Long Beach, California, United States | Recruiting |
| Cedars Sinai Medical Center | Los Angeles, California, United States | Recruiting |
| City of Hope Newport Beach | Newport Beach, California, United States | Recruiting |
| City of Hope South Pasadena | South Pasadena, California, United States | Recruiting |
| City of Hope South Bay | Torrance, California, United States | Recruiting |
| City of Hope Upland | Upland, California, United States | Recruiting |
+ 92 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05890352