● Recruiting

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Condition: Breast Cancer · Sponsor: NRG Oncology

PhasePhase 3

Planned participants3960

Who can joinFemale, 18 Years to 60 Years

Healthy volunteersNo

About this study

This Phase III Trial will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with estrogen receptor (ER)-positive, HER2-negative tumors and 21-gene recurrence score (RS) between 16-25 (for pN0 patients) and 0-25 (for pN1 patients).

This description comes directly from the study's public registry record.

Talk to the study team

Director Regulatory Affairs · 412-339-5300 · langerj@nrgoncology.org

Norman Wolmark, MD

Always discuss trial participation with your own doctor first.

Locations (1249)

University of Alabama at Birmingham Cancer Center	Birmingham, Alabama, United States	Active Not Recruiting
Anchorage Associates in Radiation Medicine	Anchorage, Alaska, United States	Recruiting
Anchorage Radiation Therapy Center	Anchorage, Alaska, United States	Suspended
Alaska Breast Care and Surgery LLC	Anchorage, Alaska, United States	Recruiting
Alaska Oncology and Hematology LLC	Anchorage, Alaska, United States	Recruiting
Alaska Women's Cancer Care	Anchorage, Alaska, United States	Recruiting
Anchorage Oncology Centre	Anchorage, Alaska, United States	Suspended
Katmai Oncology Group	Anchorage, Alaska, United States	Recruiting
Providence Alaska Medical Center	Anchorage, Alaska, United States	Recruiting
Fairbanks Memorial Hospital	Fairbanks, Alaska, United States	Recruiting
Kingman Regional Medical Center	Kingman, Arizona, United States	Recruiting
Cancer Center at Saint Joseph's	Phoenix, Arizona, United States	Recruiting

+ 1237 more locations — full list on the registry record.

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT05879926