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Study identifier: NCT05879367 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

Condition: Glioblastoma, IDH-wildtype · Glioblastoma · Glioblastoma Multiforme  ·  Sponsor: Orbus Therapeutics, Inc.

PhasePhase 1
Planned participants66
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to establish the recommended phase 2 dose of eflornithine in combination with temozolomide in patients whose glioblastoma or astrocytoma is newly diagnosed, and to evaluate safety and tolerability of this combination at that dose.

This description comes directly from the study's public registry record.

Talk to the study team

Monika Varga  ·  6506569424  ·  monika.varga@orbustherapeutics.com

Always discuss trial participation with your own doctor first.

Locations (8)

University of Alabama at BirminghamBirmingham, Alabama, United StatesWithdrawn
Henry Ford HospitalDetroit, Michigan, United StatesRecruiting
Columbia University Medical Center - Herbert Irving PavilionNew York, New York, United StatesRecruiting
Duke UniversityDurham, North Carolina, United StatesRecruiting
The Cleveland ClinicCleveland, Ohio, United StatesRecruiting
Brown University Health/Rhode Island HospitalProvidence, Rhode Island, United StatesRecruiting
UT MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
University of Utah, Huntsman Cancer InstituteSalt Lake City, Utah, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05879367