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Study identifier: NCT05878314 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Impact of Endocrine Therapy, Menstrual Cycle, PAM50, Ki67 on Treatment Decisions in HR+ and HER2- Breast Cancer

Condition: Hormone Receptor Positive HER-2 Negative Breast Cancer  ·  Sponsor: University Hospital Tuebingen

PhaseN/A
Planned participants504
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

PEAK is a prospective, multicenter, non-interventional investigator-initiated trial (IIT) that aims to investigate the influence of the menstrual cycle phase on Ki67 in patients who either receive Tamoxifen, Aromatase inhibitors ± gonadotropin-releasing hormone (GnRH)-Analogues or nothing or no preoperative endocrine treatment as part of the clinical routine. The investigators moreover address the question whether PAM50 assessment in addition to Ki67 dynamics still impacts treatment recommendations.

This description comes directly from the study's public registry record.

Talk to the study team

Dominik Dannehl, Dr.  ·  07071 29 82211  ·  Dominik.Dannehl@med.uni-tuebingen.de

Always discuss trial participation with your own doctor first.

Locations (1)

Department of Women's HealthTübingen, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT05878314