← Eichor
Study identifier: NCT05877196 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

Condition: Mild Cognitive Impairment · Alzheimer Disease · Cognitive Impairment  ·  Sponsor: Arizona State University

PhaseNA
Planned participants216
Who can joinAll sexes, 65 Years to no upper limit
Healthy volunteersYes

About this study

The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes; * identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and * examines the mechanisms of aerobic exercise's action on memory in older adults with early AD. Participants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.

This description comes directly from the study's public registry record.

Talk to the study team

Kristi Spieleder, MS  ·  480-884-2765  ·  kspieled@asu.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Arizona State UniversityPhoenix, Arizona, United StatesRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT05877196