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Study identifier: NCT05873686 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

Condition: Advanced Solid Tumor · NSCLC (Non-small Cell Lung Cancer) · Renal Cancer  ·  Sponsor: Nuvectis Pharma, Inc.

PhasePhase 1
Planned participants140
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multi-center, first-in-human, open label, dose escalation (Part A) and expansion (Part B) Phase 1 study in subjects with advanced solid tumors and in subjects with solid tumors with selected genetic alterations that are either direct (YES1 amplification) or dependent (Hippo Pathway alterations) targets of NXP900.

This description comes directly from the study's public registry record.

Talk to the study team

Erin Belshaw  ·  (201) 627-8129  ·  ebelshaw@nuvectis.com

Shay Shemesh  ·  (201) 614-3153  ·  sshemesh@nuvectis.com

Always discuss trial participation with your own doctor first.

Locations (15)

Mayo ClinicPhoenix, Arizona, United StatesRecruiting
UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting
Sarah Cannon Research Institute at HealthONEDenver, Colorado, United StatesRecruiting
Mayo ClinicJacksonville, Florida, United StatesRecruiting
University of ChicagoChicago, Illinois, United StatesRecruiting
Mayo Clinic RochesterRochester, Minnesota, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Cleveland ClinicCleveland, Ohio, United StatesRecruiting
Oregon Health and Science UniversityPortland, Oregon, United StatesRecruiting
The University of Texas MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
NEXT Oncology HoustonHouston, Texas, United StatesRecruiting
NEXT Oncology DallasIrving, Texas, United StatesRecruiting

+ 3 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05873686