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Study identifier: NCT05867251 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of AVZO-021 in Patients With Advanced Solid Tumors

Condition: Advanced Solid Tumor · HR+/HER2- Breast Cancer · HR+, HER2-, Advanced Breast Cancer  ·  Sponsor: Avenzo Therapeutics, Inc.

PhasePhase 1/Phase 2
Planned participants430
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study, the first clinical trial of AVZO-021, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and anti-tumor effects of AVZO-021 in patients with advanced solid tumors. AVZO-021 is an oral medication that inhibits cyclin-dependent kinase 2 (CDK 2).

This description comes directly from the study's public registry record.

Talk to the study team

Medical Information  ·  (858) 239-2944  ·  ClinicalTrials@avenzotx.com

Always discuss trial participation with your own doctor first.

Locations (13)

Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Florida Cancer SpecialistsSarasota, Florida, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Perlmutter Cancer Center at NYU Langone Hospital - Long IslandMineola, New York, United StatesRecruiting
NYU Langone Medical Center (Tisch Hospital)New York, New York, United StatesRecruiting
University Hospitals Cleveland Medical CenterCleveland, Ohio, United StatesRecruiting
Oklahoma UniversityOklahoma City, Oklahoma, United StatesRecruiting
Providence Cancer InstitutePortland, Oregon, United StatesRecruiting
Sidney Kimmel Cancer Center (SKCC) at Jefferson HealthPhiladelphia, Pennsylvania, United StatesRecruiting
Texas Oncology - DFWDallas, Texas, United StatesRecruiting
NEXT VirginiaFairfax, Virginia, United StatesRecruiting
Macquarie University HospitalMacquarie University, New South Wales, AustraliaRecruiting

+ 1 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05867251