Condition: Liver Transplant Failure · Prognostic Biomarkers · Sponsor: University Hospital, Ghent
The first 12 months after liver transplantation (LT) are decisive in posttransplant outcome, as almost half of deaths and two thirds of graft loss requiring retransplant occur in the first year after LT. Since delaying retransplantation in those patients that experience an unfavorable posttransplant course directly impacts their outcome, timely decision making is of paramount importance in these individuals. However, balancing the need and right timing for retransplantation in individual patients with a complicated posttransplant course is currently a difficult challenge that relies on imperfect clinical variables and biomarkers, as well as the experienced judgment of the transplant team. Building on the findings of a pilot study in liver transplant recipients (n = 131) led by the Ghent University Hospital, we want to validate the prognostic performance of the GlycoTransplantTest on a multicentric scale. In this pilot study, a single glycomic signature at day 7 after LT allowed accurate prediction of graft loss at 3 months after LT. The serum glycome of those patients experiencing graft loss was characterized by increased undergalactosylation and an increased presence of fucosylated and triantennary glycans. After statistical modeling, use of an optimized cutoff based on the relative abundance of 13 serum glycans showed a strong association with graft loss at 3 months (odds ratio 70.211; P\<0.001; 95% CI: 10.876-453.23). Using sequential measurements of serum glycomics in l…
This description comes directly from the study's public registry record.
Xavier Verhelst, MD, PhD · 0032 9 332 23 71 · xavier.verhelst@uzgent.be
Lorenz Grossar, MD · 0032 494 088 789 · lorenz.grossar@uzgent.be
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| Xavier Verhelst | Ghent, Flanders, Belgium | Recruiting |
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