← Eichor
Study identifier: NCT05866471 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

The ENHANCE Study: taVNS and Psilocybin

Condition: Healthy · Psychedelic Experiences · Vagus Nerve Stimulation  ·  Sponsor: University of Wisconsin, Madison

PhasePhase 1
Planned participants108
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersYes

About this study

This study will examine whether combining a single dose of psilocybin with non-invasive transcutaneous auricular vagus nerve stimulation (taVNS), a potential inducer of neuroplasticity and enhanced memory formation, will enhance the long-term beneficial behavioral effects of psilocybin when compared to sham taVNS or no VNS by allowing memory for insights gained during the psychedelic experience to remain vivid after they will have faded in subjects who receive psilocybin followed by sham taVNS or no VNS.

This description comes directly from the study's public registry record.

Talk to the study team

Program Manager  ·  608-265-4987  ·  enhance@psychiatry.wisc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of Wisconsin - MadisonMadison, Wisconsin, United StatesRecruiting

Follow this study

Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.

We email about this public record only. Unsubscribe anytime with one click. Never medical advice.

Is this your study? This page was generated automatically from the public registry record. Sponsors can claim it — free — to add branding and verified contact routing. Claim this page →

This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.

Source record: clinicaltrials.gov/study/NCT05866471