Condition: Recurrent Glioma · Recurrent WHO Grade 2 Glioma · Recurrent WHO Grade 3 Glioma · Sponsor: National Cancer Institute (NCI)
This phase II trial tests how well erdafitinib works in controlling IDH-wild type (WT), FGFR-TACC gene fusion positive gliomas that have come back after a period of improvement (recurrent) or that are growing, spreading, or getting worse (progressive). Erdafitinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal FGFR protein that signals tumor cells to multiply. This may help keep tumor cells from growing and may kill them. Giving erdafitinib may help to slow the growth of, or to shrink, tumor cells in patients with recurrent or progressive IDH-wild type gliomas with FGFR-TACC gene fusion.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| UCHealth University of Colorado Hospital | Aurora, Colorado, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, United States | Recruiting |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida, United States | Recruiting |
| Memorial Hospital East | Shiloh, Illinois, United States | Recruiting |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters, Missouri, United States | Recruiting |
| Siteman Cancer Center at West County Hospital | Creve Coeur, Missouri, United States | Recruiting |
| Washington University School of Medicine | St Louis, Missouri, United States | Recruiting |
| Siteman Cancer Center-South County | St Louis, Missouri, United States | Recruiting |
| Siteman Cancer Center at Christian Hospital | St Louis, Missouri, United States | Recruiting |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge, New Jersey, United States | Recruiting |
| Hackensack University Medical Center | Hackensack, New Jersey, United States | Recruiting |
+ 15 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05859334