Condition: Head and Neck Squamous Cell Carcinoma · Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University
This is an open-label, single-arm, phase II clinical trial to explore the efficacy and safety of de-escalation of postoperative radiotherapy in locally advanced head and neck squamous cell carcinoma with pathological complete response/major pathological response to neoadjuvant therapy. The eligible patients are scheduled to administered postoperative radiotherapy, PTV 50Gy/25F, instead of the standard dose of 60Gy. The overall primary study hypothesis is that reducing the dose of postoperative radiotherapy in the specific population does not affect DFS but significantly reduces treatment related adverse events.
This description comes directly from the study's public registry record.
Yingpeng Peng, Dr. · 07562526191 · pengyp3@outlook.com
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| Fifth Affiliated Hospital of Sun Yat-sen University | Zhuhai, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05854823