Condition: Ischemic Stroke · Stroke in the Young · Cardiovascular Diseases · Sponsor: Radboud University Medical Center
BACKGROUND: Worldwide, 2 million patients aged 18-50 years suffer an ischemic stroke each year with an increasing trend over the past decade due to yet unknown reasons. Whereas prognosis and antithrombotic treatment in older patients with cardiovascular disease are among the best studied topics in clinical medicine, this does not hold true for patients at young age. It is of great importance to treat these patient groups correctly to prevent recurrence and bleeding complications. However, previous research have shown that there is a long-term increased risk of recurrent ischemic events despite the secondary prevention and a subsequent increased bleeding risk. To tailor effective antithrombotic therapy to the individual patient, it is essential to understand the underlying pathogenesis and identify modifiable risk factors in young patients for recurrence or bleeding. It is thought that abnormalities of hemostasis may play a key role in early-onset ischemic stroke. First, prothrombotic conditions are associated with an increased risk for ischemic stroke at young age. In addition, disturbance of the hemostatic balance due to one or several triggers can activate the coagulation cascade, which on its turn can lead or contribute to clot formation and subsequent arterial occlusion. In previous study, there were indications that trigger factors such as fever and/or an infection in the days prior to the stroke may play a role in the pathogenesis. This suggests that an interaction betw…
This description comes directly from the study's public registry record.
Frank-Erik De Leeuw, Prof. · 0031650200314 · frankerik.deleeuw@radboudumc.nl
Janneke Spiegelenberg, MD · janneke.spiegelenberg@radboudumc.nl
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| Radboudumc | Nijmegen, Gelderland, Netherlands | Recruiting |
| Catharina Ziekenhuis | Eindhoven, North Brabant, Netherlands | Not Yet Recruiting |
| Medisch Spectrum Twente | Enschede, Overijssel, Netherlands | Not Yet Recruiting |
| Isala | Zwolle, Overijssel, Netherlands | Not Yet Recruiting |
| HagaZiekenhuis | The Hague, South Holland, Netherlands | Not Yet Recruiting |
| Medisch Centrum Leeuwarden | Leeuwarden, Netherlands | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT05853796