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Study identifier: NCT05851014 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study of GB491 in Combination With Letrozole in Patients With HR Positive and HER2 Negative Advanced Breast Cancer

Condition: Breast Cancer  ·  Sponsor: Genor Biopharma Co., Ltd.

PhasePhase 3
Planned participants350
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

The main purpose of this study is to evaluate the efficacy and safety of GB491 combined with Letrozole versus placebo combined with Letrozole in the treatment of HR+/HER2- locally advanced or metastatic breast cancer without prior systemic antitumor therapy

This description comes directly from the study's public registry record.

Talk to the study team

Yankun Fu, Master  ·  021-60751991  ·  yankun.fu@genorbio.com

Always discuss trial participation with your own doctor first.

Locations (52)

The First Affiliated Hospital of Bengbu Medical CollegeBengbu, Anhui, ChinaRecruiting
The First Hospital of Anhui Medical UniversityHefei, Anhui, ChinaRecruiting
Anhui Cancer HospitalHefei, Anhui, ChinaRecruiting
The Second Hosptial of Anhui Medical UniversityHefei, Anhui, ChinaRecruiting
Betjing Tiantan Hosptial,Capital Medical UniversityBeijing, Beijing Municipality, ChinaRecruiting
Chinese PLA General HospialBeijing, Beijing Municipality, ChinaRecruiting
The First Affiliated Hospital of Chongqing Medical UniversityChongqing, Chongqing Municipality, ChinaRecruiting
Chongqing University Cancer HospitalChongqing, Chongqing Municipality, ChinaRecruiting
Fujian Medical University Union HospitalFuzhou, Fujian, ChinaRecruiting
The First Hospital of Wenzhou Medical UniversityWenzhou, Fujian, ChinaRecruiting
The First Affiliated Hosptial of Xiamen UniversityXiamen, Fujian, ChinaRecruiting
The First People's Hospital of FoshanFoshan, Guangdong, ChinaRecruiting

+ 40 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05851014