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Study identifier: NCT05849662 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia

Condition: Leukemia, Juvenile Myelomonocytic · JMML · JCML  ·  Sponsor: Therapeutic Advances in Childhood Leukemia Consortium

PhasePhase 1/Phase 2
Planned participants58
Who can joinAll sexes, 1 Month to 21 Years
Healthy volunteersNo

About this study

This clinical trial will test the safety and efficacy of combining trametinib and azacitidine in patients with juvenile myelomonocytic leukemia (JMML). Newly diagnosed lower-risk JMML patients will receive trametinib and azacitidine. High-risk JMML patients will receive trametinib, azacitidine, fludarabine, and cytarabine.

This description comes directly from the study's public registry record.

Talk to the study team

Ellynore Florendo  ·  323-361-3022  ·  eflorendo@chla.usc.edu

Suganya Rajendran  ·  323-361-8835  ·  srajendran@chla.usc.edu

Always discuss trial participation with your own doctor first.

Locations (19)

Phoenix Children's HospitalPhoenix, Arizona, United StatesRecruiting
Children's Hospital Los AngelesLos Angeles, California, United StatesRecruiting
University of California San FranciscoSan Francisco, California, United StatesRecruiting
Children's Hospital of ColoradoDenver, Colorado, United StatesRecruiting
Children's National Medical CenterWashington D.C., District of Columbia, United StatesRecruiting
University of MiamiMiami, Florida, United StatesRecruiting
Children's Hospital of AtlantaAtlanta, Georgia, United StatesRecruiting
Lurie Children's Hospital of ChicagoChicago, Illinois, United StatesRecruiting
Indiana University/Riley Hospital for ChildrenIndianapolis, Indiana, United StatesRecruiting
Sidney Kimmel Cancer Center at Johns HopkinsBaltimore, Maryland, United StatesRecruiting
C.S. Mott Children's HospitalAnn Arbor, Michigan, United StatesRecruiting
Children's Mercy HospitalKansas City, Missouri, United StatesRecruiting

+ 7 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05849662