Condition: Alzheimer Disease · Alzheimer Disease With Delusions · Alzheimer Disease With Psychosis · Sponsor: Northwell Health
This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology. Amongst the cognitive manifestations of psychosis are impairments related to frontal circuits (social cognition, working memory and executive function deficits). The investigator's previous work suggests a role of tau pathology (one of the hallmarks of AD neuropathology) in the manifestation of psychosis in AD. However, the cerebral mechanisms that underly this association remain poorly understood. The overarching aim of the study is is to investigate the mechanisms by which tau network pathology may promote the presentation of psychosis in AD.
This description comes directly from the study's public registry record.
Erica Christen, MS · 516-562-3492 · EChriste@northwell.edu
Michelle Gong, AS · 516-562-3492 · MGong@northwell.edu
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| The Feinstein Institutes for Medical Research | Manhasset, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05847192