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Study identifier: NCT05845450 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)

Condition: Colorectal Cancer · Resectable Colorectal Carcinoma  ·  Sponsor: Gruppo Oncologico del Nord-Ovest

PhasePhase 2
Planned participants197
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a window-of-opportunity umbrella platform trial enrolling non-metastatic resectable colorectal patients selected for the presence of a specific targetable molecular alteration. The study aims to test the activity of specific targeted agents/combinations given as a short-course pre-operative strategy, matched with the specific alteration detected, followed by standard of care surgery.

This description comes directly from the study's public registry record.

Talk to the study team

Filippo Pietrantonio, MD  ·  +39 0223903807  ·  filippo.pietrantonio@istitutotumori.mi.it

Federica Palermo  ·  +39 0223903835  ·  unicornstudy@istitutotumori.mi.it

Always discuss trial participation with your own doctor first.

Locations (1)

Fondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilan, Lombardia/MI, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT05845450