Condition: Hepatocellular Carcinoma · Sponsor: Enrico De Toni
This is a randomized, open-label, multi-center, international, Phase II study to assess the efficacy and safety of sequential or up-front triple treatment with durvalumab, tremelimumab and bevacizumab for non-resectable hepatocellular carcinoma. Patients will be randomized in a 1:1 ratio to one of the following arms: Arm A: initial treatment with durvalumab plus tremelimumab followed by treatment escalation with the addition of bevacizumab upon radiological progression or in the absence of objective response Arm B: up-front treatment with durvalumab, tremelimumab and bevacizumab Patients will be stratified according to macrovascular invasion and etiology of liver disease (viral etiologies versus others).
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Hospital of the University of Munich | Munich, Germany | Recruiting |
| Klinikum Rechts der Isar of the Technical University Munich | Munich, Germany | Recruiting |
| Würzburg University Hospital | Würzburg, Germany | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05844046