Condition: Pneumonia, Ventilator-Associated · Sponsor: Hospices Civils de Lyon
Clinical presentation of patients after severe injury such as a severe infection, trauma or extensive burns is characterized by the simultaneous occurrence of dysregulation of the initial inflammatory response and immunosuppression associating quantitative and functional alterations of innate and adaptive immune cells. These acquired immune dysfunctions have been associated with an increased susceptibility to nosocomial infections, foremost among which are ventilator-associated pneumonia (VAP). Despite the implementation of a set of preventive measures, the incidence of these VAP remains high in intensive care, with rates in Europe of 1.5% per day of ventilation. Post-aggressive immunosuppression is characterized by the decrease in the expression of HLA-DR (belonging to the type II major histocompatibility complex, MHC-II) on the surface of monocytes (mHLA-DR). The administration of interferon gamma (IFNγ) can restore the level of mHLA-DR and may possibly improve the prognosis as an adjuvant therapy associated to antibiotics. However, the level of proof of this therapeutic strategy is low, limited to small cohorts of patients, or clinical studies without prior immunodepression assessment. The objective of this study is to conduct a randomized, double-blind, placebo-controlled superiority trial to assess the effect of IFNγ administration on the duration of mechanical ventilation following the first episode of VAP in patients having an HLA-DR \< 8000 AB/C All reported data ab…
This description comes directly from the study's public registry record.
Anne-Claire LUKASZEWICZ, Pr · 472 11 13 27 · anne-claire.lukaszewicz@chu-lyon.fr
Camille BOUCHENY · 4 26 73 27 39 · Camille.boucheny@chu-lyon.fr
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| CHU Limoges | Limoges, France | Not Yet Recruiting |
| Service civilo-militaire d'Anesthésie-Réanimation et Médecine Périopératoire | Lyon, France | Recruiting |
| Service de reanimation chirurgicale Hopital Croix-Rousse | Lyon, France | Not Yet Recruiting |
| Service de reanimation médicale hôpital de la Croix-Rousse | Lyon, France | Recruiting |
| Hôpital Edouard Herriot - Médecine intensive - réanimation | Lyon, France | Not Yet Recruiting |
| Service d'anesthésie-réanimation, unité de réanimation chirurgicale Picard | Nancy, France | Not Yet Recruiting |
| Médecine intensive- Réanimation | Paris, France | Recruiting |
| Service d'Anesthésie-réanimation-médecine intensive Hôpital Lyon Sud | Pierre-Bénite, France | Recruiting |
| Département Anesthésie-Réanimation | Saint-Etienne, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT05843786