Condition: Sarcoidosis, Pulmonary · Sponsor: Hospices Civils de Lyon
Sarcoidosis is a systemic granulomatous disease of unknown aetiology, mainly affecting the lungs and lymphatics. It affects people worldwide (incidence, 4.7-64/100000; prevalence, 1-36/100000/year). Although it is most often a benign acute or subacute condition, sarcoidosis may progress to a disabling chronic disease in 25% of the cases, with severe complications in about 5%, such as lung fibrosis, cardiac or neurosarcoidosis, defacing lupus pernio or blindness due to uveitis. When indicated, corticosteroids (CS) are the mainstay of treatment. Due to the kinetics of granuloma resolution, the usual and quite 'dogmatic' duration of treatment is said to be one year, following four classical steps. The long-term use of CS is hindered by cumulative toxicity and efforts have to be made to taper them, as quickly as possible, to the lowest effective dose. A recent report mentioned 39% of the CS-treated patients requiring a steroid-sparing agent. Chloroquine (CQ) and hydroxychloroquine (HCQ) are anti-malarial drugs that have been used since the 1960's as steroidsparing agents on the basis of a landmark study by Siltzbach reporting their efficacy in 43 patients with skin and intrathoracic sarcoidosis. Subsequently, two small randomized controlled trials have shown significant and prolonged improvement on pulmonary symptoms. Only small case series/reports have shown CQ/HCQ efficacy on extra-pulmonary sarcoidosis with response rates ranging from 67 to 100%. Nevertheless, CQ/HCQ are dail…
This description comes directly from the study's public registry record.
Thomas El Jammal, Dr · 04.26.73.26.29 · thomas.el-jammal@chu-lyon.fr
Camille BOUCHENY · 04 26 73 27 39 · camille.boucheny@chu-lyon.fr
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| Service de Médecine Interne Infectiologie Aïgue Polyvalente- Hôpital Henri Duffaud | Avignon, France | Recruiting |
| Service de Pneumologie - Hôpital Avicenne | Bobigny, France | Not Yet Recruiting |
| Service de medecine interne - Hôpital Henri Mondor | Créteil, France | Not Yet Recruiting |
| Service de Médecine Interne et Immunologie Clinique - CHU Dijon Bourgogne | Dijon, France | Not Yet Recruiting |
| Service de medecine interne - Hôpital Claude Huriez | Lille, France | Not Yet Recruiting |
| Service de medecine interne - Hôpital Duputryen | Limoges, France | Not Yet Recruiting |
| Service de médecine interne - Hôpital de la Croix Rousse | Lyon, France | Recruiting |
| Service de médecine interne - Hôpital Edouard Herriot | Lyon, France | Not Yet Recruiting |
| Service de médecine interne - Hôpital Lyon Sud | Lyon, France | Not Yet Recruiting |
| Service de médecine interne - Centre Hospitalier Saint Joseph Saint Luc | Lyon, France | Not Yet Recruiting |
| Service de medecine interne - Hôpital Saint Eloi | Montpellier, France | Not Yet Recruiting |
| Service de medecine interne - Hôpital Hôtel Dieu | Nantes, France | Not Yet Recruiting |
+ 9 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05841758