Condition: Pancreas Cancer · Non-Resectable Pancreas Carcinoma · Sponsor: Morten Ladekarl
The aim of the study is to compare the efficacy and toxicity of full-dose Gemcitabine and reduced-dose combination chemotherapy in patients with non-resectable pancreatic cancer, who are unfit for full-dose combination chemotherapy. The patients will be equally randomized to arm A or arm B: Arm A: Full-dose single agent treatment with Gemcitabine 1000 mg/m2 weekly on days 1, 8,and 15 every 4 weeks. Arm B: Reduced-dose (80%) combination-treatment with Gemcitabine plus Nab-Paclitaxel (Gemcitabine: 800 mg/m2 plus Nab-Paclitaxel: 100 mg/m2 on day 1, 8 and 15 every 4 weeks) Progression-free survival, overall survival and response rate will be estimated for each group, as well as toxicity and quality of life will be prospectively registered.
This description comes directly from the study's public registry record.
Morten Ladekarl, Professor · 0045+61399326 · morten.ladekarl@rn.dk
Louise Rasmussen, PhD · 0045+30226432 · loskr@rn.dk
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| Department of Oncology, Aalborg University Hospital | Aalborg, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05841420