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Study identifier: NCT05835505 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Detoxification of the Liver In PSC (Dolphin)

Condition: Primary Sclerosing Cholangitis  ·  Sponsor: Brigham and Women's Hospital

PhasePhase 2
Planned participants28
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This study is a clinical trial being done to investigate the efficacy of drug BRS201 (hydroxocobalamin) as a treatment in patients with primary sclerosing cholangitis. Participation in this study will take 8 weeks long and the study is structured as a cross-over study in which participants will take the study drug for 4 weeks and a placebo drug for 4 weeks in a randomized order in the form of an oral medication. Participation may also involve receiving an IV dose of the medication. The study will require participants to attend 9 study visits, all of which will be remote. Participation will involve taking an oral medication twice daily, tracking the medication in a log, and getting blood drawn and giving a stool sample for a few lab tests throughout the study. For the lab tests, a research nurse will visit the participant in-home for the convenience of the participant.

This description comes directly from the study's public registry record.

Talk to the study team

Sophie Mitchell, BS  ·  5089363674  ·  smitchell22@bwh.harvard.edu

Siani Ellis, BS  ·  6177325500  ·  pscresearch@bwh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Brigham and Women's HospitalChestnut Hill, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05835505