Condition: Mantle Cell Lymphoma · Mantle Cell Lymphoma Refractory · Sponsor: Australasian Leukaemia and Lymphoma Group
The goal of this clinical trial is to evaluate the safety and response of combining Pirtobrutinib and Glofitimab in patients with relapsed MCL. The main question it aims to answer are: * Will additive and synergistic effects be observed when using a combination of glofitamab and pirtobrutinib? * Will this combination be safe and lead to high complete- and remission rates with no residual disease? Pirtobrutinib will be given to all participants as an oral tablet for the duration of the entire study. Participants will receive other treatment in 3 phases: 1. Treatment Ramp-Up 1. Treatment with Obinutuzumab by Intravenous (IV) 2. An initial dose level of Glofitamab will evaluate step-up dosing. If excessive adverse events are observed, a lower initial dose will be used. 2. Fixed course combination phase: Treatment with Glofitamab by IV 3. Maintenance phase: Glofitamab is discontinued. 200mg oral daily
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Peter MacCallum Cancer Centre | Parkville, Victoria, Australia | Recruiting |
| Sir Charles Gairdener | Nedlands, Western Australia, Australia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05833763