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Study identifier: NCT05832580 Synced from ClinicalTrials.gov · July 29, 2026
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The Prevention of Systemic Ectopic Mineralization in Pseudoxanthoma Elasticum

Condition: Pseudoxanthoma Elasticum  ·  Sponsor: UMC Utrecht

PhasePhase 3
Planned participants76
Who can joinAll sexes, 18 Years to 50 Years
Healthy volunteersNo

About this study

The goal of this randomized clinical trial is to assess the effect of etidronate on ectopic calcification in relatively young patients with Pseudoxanthoma elasticum. The main question it aims to answer are: What is the difference in the arterial calcification scores in the legs and the carotid syphon measured on low-dose CT scan after 24 months of treatment compared to baseline between etidronate and placebo. Participants will be asked to do take etidronate or placebo for 24 months.

This description comes directly from the study's public registry record.

Talk to the study team

Wilko Spiering, MD, PhD  ·  + 88 755 5555  ·  w.spiering@umcutrecht.nl

Iris Harmsen, MD  ·  + 88 755 5555  ·  i.m.harmsen@umcutrecht.nl

Always discuss trial participation with your own doctor first.

Locations (1)

University Medical Center UtrechtUtrecht, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT05832580