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Study identifier: NCT05829044 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms

Condition: Normal Physiology  ·  Sponsor: Massachusetts General Hospital

PhaseNA
Planned participants48
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersYes

About this study

The goal of this clinical trial is to learn how the pupil responds to different light stimuli and how that relates to sleep and daily rhythms in healthy people of different ages. The main questions it aims to answer are: * Does the eye's pupil response to light stimuli differ by the sex and age of the participant? * Is the eye's pupil response to light stimuli related to each participant's sleep timing, their body clock timing, and their hormone responses to light. Participants will have a special eye exam and complete questionnaires before starting the study to see if they can participate. If they can participate, they will wear a special watch that monitors their activity and light levels for one week. Then they will live in a research room at the Mass General Hospital for 3 days/2 nights during which we will test their pupil response to light, their body clock timing, and their hormone responses to light.

This description comes directly from the study's public registry record.

Talk to the study team

Elizabeth B Klerman, MD PhD  ·  617-643-2424  ·  ebklerman@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05829044