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Study identifier: NCT05827081 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

Condition: Early Breast Cancer  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 3
Planned participants1400
Who can joinAll sexes, 18 Years to 100 Years
Healthy volunteersNo

About this study

The purpose of this open-label, multicenter, phase IIIb, single-arm study is to characterize the efficacy and safety of the combination of ribociclib and standard adjuvant endocrine therapy (ET) on invasive breast cancer-free survival (iBCFS), in a close to clinical practice patient population with HR-positive (HR+), HER2-negative (HER2-), Anatomic Stage Group III, IIB, and a subset of Stage IIA Early Breast Cancer (EBC).

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111  ·  novartis.email@novartis.com

Always discuss trial participation with your own doctor first.

Locations (229)

Central Alabama ResearchBirmingham, Alabama, United StatesRecruiting
Alaska Oncology and Hematology LLCAnchorage, Alaska, United StatesRecruiting
Western Reg MC-COH PhoenixGoodyear, Arizona, United StatesRecruiting
CARTI Cancer CenterLittle Rock, Arkansas, United StatesRecruiting
Beverly Hills Cancer CenterBeverly Hills, California, United StatesRecruiting
Onco Inst of Hope and InnovationCerritos, California, United StatesRecruiting
City of Hope National MedicalDuarte, California, United StatesRecruiting
Providence Medical FoundationFullerton, California, United StatesRecruiting
Los Angeles Cancer Network Good SamaritanLos Angeles, California, United StatesRecruiting
El Camino HospitalMountain View, California, United StatesRecruiting
Palo Alto Medical FoundationMountain View, California, United StatesRecruiting
UC Irvine Medical CenterOrange, California, United StatesRecruiting

+ 217 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05827081