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Study identifier: NCT05826535 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma

Condition: Relapsed Non-Hodgkin Lymphoma · Refractory Non-Hodgkin Lymphoma · Non-Hodgkin Lymphoma  ·  Sponsor: Lyell Immunopharma, Inc.

PhasePhase 1/Phase 2
Planned participants270
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase 1/2, multi-center, open-label study evaluating the safety and efficacy of rondecabtagene autoleucel (ronde-cel) also known as LYL314, a dual-targeting chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 and CD20 in participants with aggressive large B-cell lymphoma.

This description comes directly from the study's public registry record.

Talk to the study team

Stephen Simko, MD  ·  000-000-0000  ·  clinicaltrials@lyell.com

Always discuss trial participation with your own doctor first.

Locations (34)

University of California-Irvine Medical CenterIrvine, California, United StatesRecruiting
Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
University of California, Los Angeles (UCLA) Medical CenterLos Angeles, California, United StatesRecruiting
Scripps ClinicSan Diego, California, United StatesRecruiting
Colorado Blood Cancer InstituteDenver, Colorado, United StatesRecruiting
Medstar Georgetown University HospitalWashington D.C., District of Columbia, United StatesRecruiting
Augusta University Medical CenterAugusta, Georgia, United StatesRecruiting
Indiana Blood and Marrow TransplantationIndianapolis, Indiana, United StatesRecruiting
University of IowaIowa City, Iowa, United StatesRecruiting
University of Louisville Brown Cancer CenterLouisville, Kentucky, United StatesRecruiting
Louisiana State University Health Sciences CenterShreveport, Louisiana, United StatesRecruiting
Corewell HealthGrand Rapids, Michigan, United StatesRecruiting

+ 22 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05826535