Condition: Schizophrenia · Sponsor: Emory University
This study aims to illuminate the biological underpinnings of negative symptoms in schizophrenia-particularly motivational impairments-by probing the link between systemic inflammation and neural activity in reward-related brain circuits. The primary goal of this study is to determine: * Ventral Striatum Activation: Assess how reward anticipation engages the ventral striatum in individuals with schizophrenia, both before and after an anti-inflammatory intervention. * Anterior Insula Activation: Examine how increasing effort demands modulate activity in the anterior insula under the same conditions.
This description comes directly from the study's public registry record.
David R Goldsmith, MD · 404-727-3735 · drgolds@emory.edu
Corinne Dotts · corinne.jeanne.dotts@emory.edu
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| Grady Memorial Hospital | Atlanta, Georgia, United States | Recruiting |
| Emory University Hospital | Atlanta, Georgia, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05823532