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Study identifier: NCT05821959 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

Condition: Sensorineural Hearing Loss, Bilateral  ·  Sponsor: Akouos, Inc.

PhasePhase 1/Phase 2
Planned participants22
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

Part A of this trial will evaluate the safety and tolerability of a single surgical administration procedure in one or both ear(s) with one of two dose levels of AAVAnc80-hOTOF and will evaluate the Akouos Delivery Device, together with the Precision Delivery Mechanism, to safely achieve the intended product performance.

This description comes directly from the study's public registry record.

Talk to the study team

Akouos Clinical Trials  ·  +1 857-410-1816  ·  AkouosClinicalTrials@Lilly.com

Always discuss trial participation with your own doctor first.

Locations (9)

University of California, San Francisco Benioff Children's HospitalSan Francisco, California, United StatesRecruiting
University of IowaIowa City, Iowa, United StatesRecruiting
Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Cincinnati Children's Hospital Medical CenterCincinnati, Ohio, United StatesRecruiting
Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting
Vanderbilt Bill Wilkerson CenterNashville, Tennessee, United StatesRecruiting
The Hospital for Sick Children Jaina.negandhi@sickkids.ca +1 (416) 813 6683Toronto, Ontario, CanadaRecruiting
National Taiwan University HospitalTaipei, TaiwanRecruiting
University College LondonLondon, United Kingdom, United KingdomRecruiting

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Source record: clinicaltrials.gov/study/NCT05821959