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Study identifier: NCT05820841 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Acalabrutinib in Combination With R-miniCHOP in Older Adults With Untreated Diffuse Large B-Cell Lymphoma

Condition: Large B-cell Lymphoma · Diffuse Large B Cell Lymphoma  ·  Sponsor: Universität des Saarlandes

PhasePhase 3
Planned participants330
Who can joinAll sexes, 61 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to study the addition of Acalabrutinib to standard R-miniCHOP in older adults with DLBCL. The main question it aims to answer is whether progression free survival kann be prolonged with the addition of Acalabrutinib. Participants will be randomised to receive either R-miniCHOP alone or R-miniCHOP with Acalabrutinib.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (17)

Saarland University Medical CenterHomburg, Saarland, GermanyRecruiting
MVZ am Klinikum AschaffenburgAschaffenburg, GermanyNot Yet Recruiting
Helios Klinikum Emil von BehringBerlin, GermanyRecruiting
Onkologische Schwerpunktpraxis KurfürstendammBerlin, GermanyNot Yet Recruiting
Gemeinschaftspraxis Mohm/Prange-KrexDresden, GermanyNot Yet Recruiting
Universitätsklinikum Gießen und Marburg, Standort GießenGiessen, GermanyRecruiting
Universitätsmedizin GreifswaldGreifswald, GermanyRecruiting
Universitätsmedizin Halle (Saale)Halle, GermanyRecruiting
Städtisches Klinikum KarlsruheKarlsruhe, GermanyRecruiting
Johannes Wesling KlinikumMinden, GermanyNot Yet Recruiting
Rheinland Klinikum-Lukaskrankenhaus NeussNeuss, GermanyNot Yet Recruiting
Brüderkrankenhaus St. JosefPaderborn, GermanyNot Yet Recruiting

+ 5 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05820841