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Study identifier: NCT05807932 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAML

Condition: Myelodysplastic Syndromes · Secondary Acute Myeloid Leukemia · Chronic Myelomonocytic Leukemia  ·  Sponsor: Heinrich-Heine University, Duesseldorf

PhasePhase 1/Phase 2
Planned participants38
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This trial aims to find the MTD of Venetoclax when added to Fludarabin, Amsacrine and Ara-C + Treosulfan and to evaluate whether the addition of Venetoclax to sequential conditioning with FLAMSA + Treosulfan is safe for allogeneic blood stem cell transplantation in patients with high-risk MDS, CMML or sAML (FLAMSAClax)

This description comes directly from the study's public registry record.

Talk to the study team

Guido Kobbe, Prof. Dr.  ·  +492118116  ·  kobbe@med.uni-duesseldorf.de

Always discuss trial participation with your own doctor first.

Locations (6)

Universitätsklinikum Aachen - Med. Klinik IVAachen, North Rhine-Westphalia, GermanyRecruiting
Universitätsklinikum Düsseldorf - Klinik für Hämatologie, Onkologie und Klinische ImmunologieDüsseldorf, North Rhine-Westphalia, GermanyRecruiting
Universitätsklinikum Köln Klinik I für Innere MedizinCologne, GermanyRecruiting
Universitätsklinikum Frankfurt Medizinische Klinik IIFrankfurt, GermanyRecruiting
Universitätsklinikum Jena - Klinik für Innere Medizin IIJena, GermanyRecruiting
Klinikum rechts der Isar der TU München Klinik und Poliklinik für Innere Medizin IIIMünchen, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT05807932